Azelaic acid
| Parameter | Analysis result |
|---|---|
| The purity and color of the solution | 5ml 1% 1N NaOH solution, clean and transparent |
| Chlorides | <0.005% |
| Sulfates | <0.025% |
| Heavy metals | <0.001% |
| Iron | <0.002% |
| C9H16O4 | 99.8% |
Azelaic acid (nonandioic acid) HOOC (CH2) 7COOH is a dibasic terminal carboxylic acid. It has all the chemical properties characteristic of carboxylic acids. Salts and esters of azelaic acid are called azelainates. During the pyrolysis of its water-insoluble salts (Ca, Mn), cyclooctanone is formed.
Properties
Azelaic acid has the same physical and chemical properties as carboxylic acids. Deep permeability provides a good effect when used for cosmetic purposes. The substance is poorly soluble in water at room temperature, has a high flammability threshold. After entering the body is transformed into dicarboxylic acids, which are easier absorbed by the human body. With prolonged use in small concentrations azelaine ointment is not addictive.
pharmachologic effect
After application to the skin, ointment with acid penetrates into the epidermis and dermis, part of it is absorbed into the bloodstream. Does not cause roughness of the surface layer of the skin. The maximum effect from the use of creams occurs 2-4 weeks after the start of application. The organic agent has the following effects on the skin:
slows the formation of age spots;
regulates sebum production;
protects the skin from keratinization;
has anti-inflammatory effect;
helps to slow the growth of bacteria and the production of fatty acids that cause the formation of acne;
promotes self-cleaning of cells and ducts of the sebaceous gland;
has an antibacterial effect;
protects against the appearance of comedones.
Shiping
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